Endocrine Abstracts

Background: Brown tumor of bone is a non-neoplastic lesion resulting from abnormal bone metabolism in hyperparathyroidism. Brown tumor, as the only and initial symptom of normocalcemic primary hyperparathyroidism is extremely rare.Case presentation: A 69-year-old female patient was admitted to the hospital with a mass in the right thigh. A mass lesion of the right distal femur with bone and soft tissue infiltration was observed in the lower extremity mag...

Background: Obesity and diabetes are major causes of morbidity and mortality that are increasing all over the world. As obesity is a major risk factor for type 2 diabetic patients, weight loss has an important place in the treatment of type 2 diabetic patients. In our study, it’s aimed to evaluate the effects of exenatide and laparoscopic sleeve gastrectomy (LSG) in obese diabetic patients on the clinical and laboratory parameters.Subjects and metho...

Background: Aggressive pituitary adenomas (APAs) take place phenotypically between benign pituitary adenomas and pituitary carcinomas with systemic metastasis. Frequent recurrence and resistance to conventional treatments are characteristic features of APAs in their clinical course. Temozolomide is an alkylating agent that has been used in the treatment of pituitary carcinomas and APAs since 2006. Herein, we report a patient who received temozolomide treatment due to APA.<...

Background: Because of prolong exposure to elevated endogenous growth hormone (GH) and insulin-like growth factor (IGF-1) levels in acromegaly, it is resulted in multipl comorbidities such as somatic growth, hypertension, diabetes and sleep apnea. Systemic complications caused by acromegaly include gastrointestinal (GIS) involvement. In our study it was planned to evaluate the upper GIS findings by using endoscopic and ultrasonographic methods in acromegaly patients.<p cla...

Introduction: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy, with an incidence in the literature of 0.5 to 2 cases per million population per year. The most important prognostic factors are stage of cancer at the time of diagnosis and success of the first surgery. However, advanced age, tumor size, functionality, high Ki-67 index (>10%), necrosis, and high mitotic activity are among poor prognostic factors.Patients and method: Fifteen...

Introduction: Generally, symptoms of celiac disease is not accompanied when present together with autoimmune endocrine diseases. In this study, we aimed to investigate the prevalence of silent celiac disease in the APS and autoimmune monoglandular disorders by measuring tissue transglutaminase antibodies (ttgAb).Methods: A total of 103 patients with monaglandular or polyglandular autoimmune endocrine disorders and 32 control subjects were enrolled in the...

Introduction: Spondyloepiphyseal dysplasia congenita (SEDC) is a rare congenital disease of skeletal system,which is characterized by short stature, shortage of trunk and mostly affect vertebral column and epiphysis of long bones. In this case report, we aimed to represent a patient complaining of short stature and referred to our hospital,who was detected to have an early onset osteoporosis accompanied by proximal femoral aplasia; in the light of literature.<p class="abst...

Introduction: Vitamin D Deficiency has been widely regarded as contributing to autoimmune disease, but low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause like from malabsorbtion due to celiac disease, gastrointestinal disorders related to diabetes or thyroid disease, corticosteroid therapy complications etc\..In this study, we aimed to investigate vitamin d levels in autoimmune endocrine disorders and relationship with silent celiac...

One of the main problems encountered with increased levels of serum PTH is decrease in bone mineral density in the long term. Secondary hyperparathyroidism due to vitamin D deficiency leads to mineralization disorders of the bones, low bone mineral density, osteoporosis and ultimately an increased risk of bone fracture in adults. In this study, we aimed to determine the reasons of secondary hyperparathyroidism for bone mineral density.One hundred and thi...

In this study, we aimed to investigate the causes of elevated PTH levels in postmenopausal women without the use of drugs that may affect of PTH levels and without concomitant diseases.A total of 156 postmenopausal women, aged ≥ 50 years, had no menstruation for at least 2 years and had no disease known to affect calcium metabolism were considered. Education, occupation, average duration of exposure to sunlight per day in summer and winter, consump...